.Authors and AffiliationsDana-Farber Cancer Principle, Brigham and Womenu00e2 $ s Medical facility as well as Harvard Medical Institution, Boston Ma, MA, USAToni K. Choueiriu00c2 & u00c2 William G. Kaelin JrHoward Hughes Medical Principle, Chevy Chase, MD, USAWilliam G. Kaelin JrCorresponding authorsCorrespondence to.Toni K. Choueiri or William G. Kaelin Jr.